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Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia
- Source :
- Neuroscience Letters. 378:102-105
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Dysfunction of the N-methyl-D-aspartate (NMDA) type glutamate receptor has been proposed as a mechanism in the etiology of schizophrenia. Recently, we identified a variable (GT)n repeat in the promoter region of the NMDA NR2A subunit gene (GRIN2A), and showed its association with schizophrenia in a case-control study, together with a correlation between the length of the repeat and severity of chronic outcome. In this study, we extended our analyses, by increasing the number of case-control samples to a total of 672 schizophrenics and 686 controls, and excluded potential sample stratification effects. We confirmed the significant allelic association between the repeat polymorphism and disease (P = 0.011), and as in the previous study, we observed an over-representation of longer alleles in schizophrenia. These results suggest a probable genetic effect for the GRIN2A promoter (GT)n variation on the predisposition to schizophrenia in Japanese cohorts.
- Subjects :
- Adult
Male
Psychosis
Receptors, N-Methyl-D-Aspartate
Cohort Studies
Chromosome 16
Japan
medicine
Humans
Genetic Predisposition to Disease
RNA, Messenger
Bipolar disorder
Allele
Dinucleotide Repeats
Promoter Regions, Genetic
Gene
Genetics
Chi-Square Distribution
Polymorphism, Genetic
biology
Reverse Transcriptase Polymerase Chain Reaction
General Neuroscience
Promoter
Middle Aged
medicine.disease
Protein Subunits
Schizophrenia
biology.protein
NMDA receptor
GRIN2A
Female
Psychology
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 378
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....d014a830ef884b11975d65ca1499e5d4