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Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE
- Source :
- Kristensen, A G, Bostock, H, Finnerup, N B, Andersen, H, Jensen, T S, Gylfadottir, S, Itani, M, Krøigård, T, Sindrup, S & Tankisi, H 2019, ' Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE ', Clinical Neurophysiology, vol. 130, no. 10, pp. 1981-1987 . https://doi.org/10.1016/j.clinph.2019.08.003
- Publication Year :
- 2019
-
Abstract
- Hospital Aim To examine whether a novel MUNE method so called MScanFit MUNE (MScan) can detect early motor involvement in diabetic polyneuropathy (DPN). Methods In this study, 100 patients with diabetes mellitus type II will be prospectively included as a part of International Diabetic Neuropathy Consortium (IDNC) project. Preliminary results of 24 patients (18 males, 6 females, mean age: 63, range: (44–74) will be presented here. Nerve conduction studies (NCS) of three motor (median, peroneal, tibial) and three sensory (bilateral sural and median) nerves and MScan in abductor pollicis brevis (APB) muscle were done in all patients.NCS results were compared to laboratory controls. MScan results were compared to 20 age-matched healthy subjects. Results From NCSs, DPN was classified by Dyck’s criteria. Six of 24 patients (25%) had DPN while 18 patients had normal NCS. None of the 24 patients had decreased CMAP amplitude of median nerve. MScan was abnormal in eight of 24 patients (33%). Of these eight, two patients had DPN and six had normal NCS. Discussion Normal MScan in patients with DPN may be due to length dependent feature of DPN, thereby unaffected upper extremities as these patients had slight sensory neuropathy. However, MScan could detect abnormality in nerves with normal CMAP amplitude and normal NCS. Conclusion MScan may improve electrodiagnosis of DPN by detection of early motor involvement and motor unit loss. Significance MScan is a promising novel method which may be useful in quantifying motor unit loss in different neuromuscular disorders including DPN.
- Subjects :
- Adult
Male
Recruitment, Neurophysiological
Mscan
medicine.medical_specialty
Diabetic polyneuropathy
Diabetic neuropathy
Neural Conduction
Urology
Action Potentials
behavioral disciplines and activities
050105 experimental psychology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Diabetic Neuropathies
Motor involvement
Physiology (medical)
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
In patient
Muscle, Skeletal
CMAP amplitude
Aged
Aged, 80 and over
Motor Neurons
business.industry
05 social sciences
Healthy subjects
Mean age
MScanFit MUNE
Middle Aged
medicine.disease
Sensory Systems
Median nerve
Motor unit
Diabetes Mellitus, Type 2
Neurology
Female
Neurology (clinical)
Nerve conduction studies
Abnormality
business
DPN
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Kristensen, A G, Bostock, H, Finnerup, N B, Andersen, H, Jensen, T S, Gylfadottir, S, Itani, M, Krøigård, T, Sindrup, S & Tankisi, H 2019, ' Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE ', Clinical Neurophysiology, vol. 130, no. 10, pp. 1981-1987 . https://doi.org/10.1016/j.clinph.2019.08.003
- Accession number :
- edsair.doi.dedup.....d0083e11e2cb5a38a603ded8022d8f24