Back to Search Start Over

Adult neurogenesis and the future of the rejuvenating brain circuits

Authors :
Antoine Nissant
Gabriel Lepousez
Pierre-Marie Lledo
Perception et Mémoire / Perception and Memory
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
This work was supported by the life insurance company Humanis and the Agence Nationale de la Recherche (ANR-BLAN-SVSE4-LS-110624 and PLASTMATBEHAV). Our laboratory is also part of the École des Neurosciences de Paris (ENP) Ile-de-France network, and it is supported by French state funds managed by the ANR within the Investissements d’Avenir programme 'Biopsy' and 'Revive.'
ANR-12-BSV7-0017,PLASTMATBEHAV,Contribution de la neurogenèse olfactive à la mise en place du comportement maternel chez les mammifères.(2012)
ANR-15-CE37-0004,SmellBrain,Dissection fonctionnelle des circuits codant pour la récompense dans le système olfactif(2015)
ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011)
ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010)
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Source :
Neuron, Neuron, Elsevier, 2015, 86 (2), pp.387-401. ⟨10.1016/j.neuron.2015.01.002⟩, Neuron, 2015, 86 (2), pp.387-401. ⟨10.1016/j.neuron.2015.01.002⟩
Publication Year :
2015
Publisher :
HAL CCSD, 2015.

Abstract

International audience; For a long time, the mammalian brain has been perceived to be a static organ. However, the discovery of adult neurogenesis in most mammalian species, including humans, monkeys, and rodents, has disrupted this view. As this continuous regeneration has an effect on established behavioral patterns, it holds promising therapeutic potential. However, before harnessing this potential regenerative power, we must understand what effects new neurons have on existing brain circuits. Ongoing research contributes to several important steps toward bridging the gap between adult-born neurons, circuits, and behavior. The study of adult neurogenesis in different neurogenic regions from a systems neuroscience perspective will pave the way to understanding how it supports adaptive behavior and why its dysfunction correlates with some human brain disorders.

Details

Language :
English
ISSN :
08966273
Database :
OpenAIRE
Journal :
Neuron, Neuron, Elsevier, 2015, 86 (2), pp.387-401. ⟨10.1016/j.neuron.2015.01.002⟩, Neuron, 2015, 86 (2), pp.387-401. ⟨10.1016/j.neuron.2015.01.002⟩
Accession number :
edsair.doi.dedup.....cffeb4389868286d0693571d1453afd5
Full Text :
https://doi.org/10.1016/j.neuron.2015.01.002⟩