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Vitamin D and Hospital Admission in Older Adults: A Prospective Association
- Source :
- Nutrients, Vol 13, Iss 616, p 616 (2021), Nutrients, Volume 13, Issue 2
- Publication Year :
- 2021
-
Abstract
- The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital admission and emergency department (ED) attendance. Trinity University of Ulster Department of Agriculture (TUDA) is a large cross-sectional study of older adults with a community population from three disease-defined cohorts (cognitive dysfunction, hypertension, and osteoporosis). Participants included in this analysis were recruited between 2008 and 2012. ED and hospital admission data were gathered from the date of TUDA participation until June 2013, with a mean follow up of 3.6 years. Of the 3093 participants, 1577 (50.9%) attended the ED during the period of follow-up. Attendees had lower mean serum 25(OH)D concentrations than non-attendees (59.1 vs. 70.6 nmol/L). Fully adjusted models showed an inverse association between vitamin D and ED attendance (Hazard Ratio (HR) 0.996<br />95% Confidence Interval (CI) 0.995–0.998<br />p &lt<br />0.001). A total of 1269 participants (41%) were admitted to hospital during the follow-up. Those admitted had lower mean vitamin D concentrations (58.4 vs. 69.3 nmol/L, p &lt<br />0.001). In fully adjusted models, higher vitamin D was inversely associated with hospital admission (HR 0.996<br />95% CI 0.994–0.998<br />0.001) and length of stay (LOS) (β = −0.95, p = 0.006). This study showed independent prospective associations between vitamin D deficiency and increased hospitalisation by older adults. The need for further evaluation of current recommendations in relation to vitamin D supplementation, with consideration beyond bone health, is warranted and should focus on randomised controlled trials.
- Subjects :
- Male
medicine.medical_specialty
Osteoporosis
Nutritional Status
lcsh:TX341-641
030204 cardiovascular system & hematology
Article
vitamin D deficiency
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Vitamin D and neurology
Humans
030212 general & internal medicine
Prospective Studies
Vitamin D
Aged
Proportional Hazards Models
Aged, 80 and over
Nutrition and Dietetics
hospitalisation
business.industry
Hazard ratio
Attendance
emergency department attendance
Emergency department
Patient Acceptance of Health Care
medicine.disease
Vitamin D Deficiency
Confidence interval
Hospitals
Hospitalization
hospital admission
Cross-Sectional Studies
Hospital admission
resource utilisation
Female
business
Emergency Service, Hospital
lcsh:Nutrition. Foods and food supply
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....cff7f84e8238dc36cf3c3fbdfcae6d39