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Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
- Source :
- Frontiers in Oncology, Vol 10 (2020), Frontiers in Oncology
- Publication Year :
- 2020
- Publisher :
- Frontiers Media S.A., 2020.
-
Abstract
- Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Malignant brain tumor
cancer predisposition
Review
Settore MED/04
medulloblastoma
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Internal medicine
Epidemiology
medicine
genetic syndrome
neoplasms
cancer genes
cancer syndromes
hereditary neoplastic syndromes
pediatric brain tumors
Medulloblastoma
brain tumors
business.industry
Cancer predisposition
Cancer
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
nervous system diseases
stomatognathic diseases
030104 developmental biology
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
030220 oncology & carcinogenesis
Cancer gene
business
Subjects
Details
- Language :
- English
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Oncology
- Accession number :
- edsair.doi.dedup.....cfdd06a92387f4b1303f70b7de1a97d8