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Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects
- Source :
- Phytochemistry. 187
- Publication Year :
- 2020
-
Abstract
- Phytochemical studies on the root of Abrus precatorius Linn. (Fabaceae), leads towards the identification of four undescribed (abruquinones M, N, O, and P), and seven known abruquinones, (abruquinones A, E, B, F, I, D, and G). Spectroscopic analyses (1D, and 2D NMR, HRESI-MS) were used in elucidating structures of the all compounds. Evaluation of anticancer activities of the isolated isoflavanquinones revealed that abruquinones M, and N showed cytotoxicity against oral CAL-27 (IC50 values 6.48 and 5.26 μM, respectively), and colon (Caco-2) cell lines (IC50 values 15.79 and 10.33 μM, respectively). Abruquinone M also inhibited the growth of lung cancer cells (NCI–H460) with IC50 of 31.33 μM. The isolated isoflavanquiones also showed potent anti-inflammatory potential through phagocyte oxidative burst and pro-inflammatory cytokine TNF-α inhibition in vitro. These findings suggest isoflavanquinones from A. precatorius roots as candidates for further research in cancer treatment.
- Subjects :
- Phagocyte
biology
Chemistry
medicine.drug_class
medicine.medical_treatment
Fabaceae
Plant Science
General Medicine
Horticulture
Pharmacology
biology.organism_classification
Biochemistry
Anti-inflammatory
medicine.anatomical_structure
Cytokine
Phytochemical
Cell culture
Abrus precatorius
Abrus
medicine
Cytotoxicity
Molecular Biology
IC50
Subjects
Details
- ISSN :
- 18733700
- Volume :
- 187
- Database :
- OpenAIRE
- Journal :
- Phytochemistry
- Accession number :
- edsair.doi.dedup.....cfd3b3a4fea56fb57f200b984f965a7e