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Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: a randomized pilot study
- Source :
- Breast Cancer Res Treat
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- The purpose of this study was to determine the effects of an 8-week high-intensity interval training (HIIT) intervention on vascular endothelial function, measured as brachial artery flow-mediated dilation (baFMD), and vascular wall thickness measured by carotid intima media thickness (cIMT) in breast cancer patients undergoing anthracycline-based chemotherapy. Thirty women were randomized to either HIIT or non-exercise control groups (CON). The HIIT group participated in an 8-week HIIT intervention occurring three times per week on a cycle ergometer. The CON group was offered the HIIT intervention after 8 weeks. baFMD was measured from the brachial artery diameter at baseline (D0) and 1 min after cuff deflation (D1); percent change was calculated by measuring brachial artery diameter after cuff deflation relative to the baseline [baFMD = (D1 − D0)/D0 × 100]. The cIMT was obtained from the posterior wall of common carotid artery 10 mm below the carotid bulb. Paired t test and repeated measures ANCOVA were performed to assess changes in baFMD and cIMT. At baseline, the HIIT (n = 15) and CON (n = 15) groups did not differ by age (46.9 ± 9.8 years), BMI (31.0 ± 7.5 kg/m2), and blood pressure (123.4 ± 16.8/72.3.9 ± 5.6 mmHg). Post-exercise, baFMD significantly increased [4.3; 95% confidence interval (CI): (1.5, 7.0), p = 0.005] in HIIT versus CON group. cIMT did not significantly change [0.003, 95% CI − 0.004, 0.009), p = 0.40] in HIIT group, while IMT significantly increased from baseline to post-intervention (0.009, 95% CI 0.004, 0.010, p = 0.003) in CON group. This study may suggest that HIIT improved vascular endothelial function and maintained wall thickness in breast cancer patients undergoing anthracycline-based chemotherapy. Trial registration: ClinicalTrials.gov: NCT02454777.
- Subjects :
- Adult
0301 basic medicine
Cancer Research
medicine.medical_specialty
Breast Neoplasms
Pilot Projects
High-Intensity Interval Training
Carotid Intima-Media Thickness
Article
Interval training
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine.artery
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Anthracyclines
Common carotid artery
Brachial artery
Neoplasm Staging
business.industry
Repeated measures design
Middle Aged
Combined Modality Therapy
Confidence interval
Exercise Therapy
Treatment Outcome
030104 developmental biology
Blood pressure
Oncology
Intima-media thickness
030220 oncology & carcinogenesis
Cardiology
Female
Endothelium, Vascular
business
High-intensity interval training
Subjects
Details
- ISSN :
- 15737217, 01676806, and 02454777
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....cfd1d5a446134bd30a74ff2aecaf65c9