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Hyperprogression Under Immune Checkpoint-Based Immunotherapy—Current Understanding, The Role of PD-1/PD-L1 Tumour-Intrinsic Signalling, Future Directions and a Potential Large Animal Model
- Source :
- Cancers, Vol 12, Iss 804, p 804 (2020), Kocikowski, M, Dziubek, K & Parys, M 2020, ' Hyperprogression Under Immune Checkpoint-Based Immunotherapy—Current Understanding, The Role of PD-1/PD-L1 Tumour-Intrinsic Signalling, Future Directions and a Potential Large Animal Model ', Cancers . https://doi.org/10.3390/cancers12040804, Cancers
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Immune evasion is a major challenge for the development of successful cancer treatments. One of the known mechanisms is the expression of immune checkpoints (ICs)—proteins regulating the immune cells activation. The advent of immunotherapy using monoclonal antibodies (mAbs) to block the immune checkpoint receptor-ligand interaction brought about a landslide improvement in the treatment responses, leading to a prompt approval of such therapeutics. In recent years, it was discovered that a subset of patients receiving IC blockade treatment experienced a previously unknown pattern of treatment response called hyperprogression (HP), characterised by rapid deterioration on initialisation of the therapy. HP represents an urgent issue for clinicians and drug developers, while posing questions about the adequacy of the current clinical trial process. Here, we briefly summarise the state of knowledge and propose new directions for research into HP mechanisms, focusing on tumour-intrinsic signalling of IC proteins malignantly expressed by cancer. We also discuss the potential role of spontaneously occurring canine cancer in the assessment of immunotherapeutics, which can provide the missing link between murine and human studies.
- Subjects :
- PD-L1
0301 basic medicine
Cancer Research
medicine.drug_class
comparative oncology
medicine.medical_treatment
Review
Monoclonal antibody
hyperprogression
lcsh:RC254-282
canine model
03 medical and health sciences
0302 clinical medicine
Immune system
PD-1
medicine
cancer
biology
business.industry
Cancer
Immunotherapy
immune checkpoint blockade
medicine.disease
hyperprogressive disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immune checkpoint
Blockade
Clinical trial
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
biology.protein
immunotherapy
business
Neuroscience
tumour-intrinsic signalling
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 12
- Issue :
- 804
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....cfc9e5d13bde327ddf5e56f721af8d69