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BLOS2 maintains hematopoietic stem cells in the fetal liver via repressing Notch signaling
- Source :
- Experimental hematology. 51
- Publication Year :
- 2016
-
Abstract
- During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) after their emergence in the aorta–gonad–mesonephros (AGM) region. We recently reported that the endolysosomal trafficking factor BLOS2, encoded by the Bloc1s2 gene, regulates HSC/hematopoietic progenitor cell emergence in the AGM region; however, whether it plays a role in the FL remains unknown. Here, we show that BLOS2 plays an essential role in the regulation of HSC proliferation and differentiation in the FL. Bloc1s2 depletion leads to elevated Notch signaling, with an increased frequency but weakened self-renewal ability of FL HSCs. Functional assays show that Bloc1s2 −/− FL HSCs harbor impaired lymphoid and myeloid differentiation abilities. These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during FL hematopoiesis.
- Subjects :
- 0301 basic medicine
Cancer Research
Myeloid
Liver cytology
Cell
Notch signaling pathway
Biology
03 medical and health sciences
Mice
Fetus
Genetics
medicine
Animals
Humans
Receptor
Molecular Biology
Cell Proliferation
Mice, Knockout
Receptors, Notch
Proteins
Cell Differentiation
Cell Biology
Hematology
Hematopoietic Stem Cells
Cell biology
Haematopoiesis
030104 developmental biology
medicine.anatomical_structure
Liver
Hematopoiesis, Extramedullary
Immunology
Stem cell
Homeostasis
Subjects
Details
- ISSN :
- 18732399
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Experimental hematology
- Accession number :
- edsair.doi.dedup.....cfba6f4d19a04854f883a59e2ff8322c