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Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats
- Source :
- Journal of the Chinese Medical Association, Vol 78, Iss 2, Pp 114-120 (2015)
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Background The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng , were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng . Conclusion The combination of SalB and Rg1 may provide potential protection against myocardial infarction.
- Subjects :
- Male
Cardiotonic Agents
Ginsenosides
Myocardial Infarction
acute myocardial infarction
Panax notoginseng
Salvia miltiorrhiza
Pharmacology
Anterior Descending Coronary Artery
salvianolic acid B
Contractility
Cerebral circulation
ginsenoside Rb1
medicine
Animals
Myocardial infarction
Rats, Wistar
Benzofurans
Medicine(all)
Cardioprotection
lcsh:R5-920
biology
business.industry
General Medicine
biology.organism_classification
medicine.disease
Rats
ginsenoside Rg1
Drug Combinations
lcsh:Medicine (General)
Ligation
business
Subjects
Details
- ISSN :
- 17264901
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of the Chinese Medical Association
- Accession number :
- edsair.doi.dedup.....cfb6e871f15db8575b308a53d968279f