Back to Search
Start Over
Random partitions approximating the coalescence of lineages during a selective sweep
- Source :
- Ann. Appl. Probab. 15, no. 3 (2005), 1591-1651
- Publication Year :
- 2004
- Publisher :
- arXiv, 2004.
-
Abstract
- When a beneficial mutation occurs in a population, the new, favored allele may spread to the entire population. This process is known as a selective sweep. Suppose we sample $n$ individuals at the end of a selective sweep. If we focus on a site on the chromosome that is close to the location of the beneficial mutation, then many of the lineages will likely be descended from the individual that had the beneficial mutation, while others will be descended from a different individual because of recombination between the two sites. We introduce two approximations for the effect of a selective sweep. The first one is simple but not very accurate: flip $n$ independent coins with probability $p$ of heads and say that the lineages whose coins come up heads are those that are descended from the individual with the beneficial mutation. A second approximation, which is related to Kingman's paintbox construction, replaces the coin flips by integer-valued random variables and leads to very accurate results.
- Subjects :
- Statistics and Probability
Population
Coalescence
01 natural sciences
selective sweep
Combinatorics
010104 statistics & probability
FOS: Mathematics
60J85
0101 mathematics
education
Quantitative Biology - Populations and Evolution
Mathematics
Coalescence (physics)
random partition
Entire population
education.field_of_study
010102 general mathematics
Probability (math.PR)
Populations and Evolution (q-bio.PE)
92D10
hitchhiking
92D15
05A18
FOS: Biological sciences
mutation
Statistics, Probability and Uncertainty
Selective sweep
Random variable
Mathematics - Probability
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Ann. Appl. Probab. 15, no. 3 (2005), 1591-1651
- Accession number :
- edsair.doi.dedup.....cfaf5604fb88f5e9d297986526498bf1
- Full Text :
- https://doi.org/10.48550/arxiv.math/0411069