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Incorporation of nanogels within calcite single crystals for the storage, protection and controlled release of active compounds†
- Source :
- Chemical Science, 'Chemical Science ', vol: 12, pages: 9839-9850 (2021)
- Publication Year :
- 2021
- Publisher :
- The Royal Society of Chemistry, 2021.
-
Abstract
- Nanocarriers have tremendous potential for the encapsulation, storage and delivery of active compounds. However, current formulations often employ open structures that achieve efficient loading of active agents, but that suffer undesired leakage and instability of the payloads over time. Here, a straightforward strategy that overcomes these issues is presented, in which protein nanogels are encapsulated within single crystals of calcite (CaCO3). Demonstrating our approach with bovine serum albumin (BSA) nanogels loaded with (bio)active compounds, including doxorubicin (a chemotherapeutic drug) and lysozyme (an antibacterial enzyme), we show that these nanogels can be occluded within calcite host crystals at levels of up to 45 vol%. Encapsulated within the dense mineral, the active compounds are stable against harsh conditions such as high temperature and pH, and controlled release can be triggered by a simple reduction of the pH. Comparisons with analogous systems – amorphous calcium carbonate, mesoporous vaterite (CaCO3) polycrystals, and calcite crystals containing polymer vesicles – demonstrate the superior encapsulation performance of the nanogel/calcite system. This opens the door to encapsulating a broad range of existing nanocarrier systems within single crystal hosts for the efficient storage, transport and controlled release of various active guest species.<br />Nanocarriers have tremendous potential for the encapsulation, storage and delivery of active compounds.
- Subjects :
- chemistry.chemical_classification
Calcite
FOS: Nanotechnology
34 Chemical Sciences
Chemistry
Bioengineering
02 engineering and technology
General Chemistry
Polymer
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Controlled release
Amorphous calcium carbonate
0104 chemical sciences
3402 Inorganic Chemistry
chemistry.chemical_compound
Chemical engineering
Vaterite
Nanotechnology
Nanocarriers
0210 nano-technology
Mesoporous material
Nanogel
Subjects
Details
- Language :
- English
- ISSN :
- 20416539 and 20416520
- Volume :
- 12
- Issue :
- 28
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi.dedup.....cfa04014104709d65bf72c34b8b89749