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Gene signature predictive of hepatocellular carcinoma patient response to transarterial chemoembolization
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2019
- Publisher :
- Ivyspring International Publisher, 2019.
-
Abstract
- Transarterial chemoembolization (TACE) is a commonly used treatment modality in hepatocellular carcinoma (HCC). The ability to identify patients who will respond to TACE represents an important clinical need, and tumor gene expression patterns may be associated with TACE response. We investigated whether tumor transcriptome is associated with TACE response in patients with HCC. We analyzed transcriptome data of treatment-naive tumor tissues from a Chinese cohort of 191 HCC patients, including 105 patients who underwent TACE following resection with curative intent. We then developed a gene signature, TACE Navigator, which was associated with improved survival in patients that received either adjuvant or post-relapse TACE. To validate our findings, we applied our signature in a blinded manner to three independent cohorts comprising an additional 130 patients with diverse ethnic backgrounds enrolled in three different hospitals who received either adjuvant TACE or palliative TACE. TACE Navigator stratified patients into Responders and Non-Responders which was associated with improved survival following TACE in our test cohort (Responders: 67 months vs Non-Responders: 39.5 months, p
- Subjects :
- Oncology
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
medicine.medical_treatment
Improved survival
Patient response
Applied Microbiology and Biotechnology
gene signature
Cohort Studies
03 medical and health sciences
Transarterial Chemoembolization
hypoxia signaling
Internal medicine
medicine
Humans
In patient
Genetic Predisposition to Disease
Chemoembolization, Therapeutic
Molecular Biology
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
0303 health sciences
business.industry
Proportional hazards model
Liver Neoplasms
treatment response
Cell Biology
hepatocellular carcinoma
Gene signature
Middle Aged
medicine.disease
3. Good health
Hepatocellular carcinoma
precision oncology
Cohort
Female
business
Adjuvant
Developmental Biology
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 14492288
- Volume :
- 15
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....cf9f31ff0d6c6d8fedabc45f9df1deac