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Pathophysiologic characteristics of the activity-stress paradigm in animal models: inhibitory effect of glucose on these responses
- Source :
- Nutrition reviews. 61(5 Pt 2)
- Publication Year :
- 2003
-
Abstract
- This review provides a discussion of the pathophysiologic significance of animal models of the activity-stress paradigm and the role of plasma glucose level in the appearance of physical stress responses of those models. Many research reports have demonstrated that animal models exposed to activity-stress are useful as a “symptomatic model” of anorexia nervosa and obsessive-compulsive disorder as well as peptic ulcer. Our findings show that a decrease in plasma glucose concentration is an important factor in determining the activity-stress-induced physical responses. Further investigation of the pathophysiology of activity-stressed animal models may contribute to the development of new therapeutics for diseases such as anorexia nervosa and obsessive-compulsive disorder.
- Subjects :
- Blood Glucose
medicine.medical_specialty
Obsessive-Compulsive Disorder
Anorexia Nervosa
Physical Exertion
Medicine (miscellaneous)
Anorexia
Plasma glucose level
Stress, Physiological
Internal medicine
mental disorders
medicine
Animals
Inhibitory effect
Nutrition and Dietetics
business.industry
Plasma glucose concentration
medicine.disease
Pathophysiology
Rats
Disease Models, Animal
Endocrinology
Glucose
Anorexia nervosa (differential diagnoses)
Peptic ulcer
Activity stress
medicine.symptom
business
Food Deprivation
Neuroscience
Subjects
Details
- ISSN :
- 00296643
- Volume :
- 61
- Issue :
- 5 Pt 2
- Database :
- OpenAIRE
- Journal :
- Nutrition reviews
- Accession number :
- edsair.doi.dedup.....cf9e32214d787c480419fcd05f71fe36