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Functional connectivity hemispheric contrast (FC-HC): A new metric for language mapping
- Source :
- NeuroImage: Clinical, Vol 30, Iss, Pp 102598-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Development of a task-free method for presurgical mapping of language function is important for use in young or cognitively impaired patients. Resting state connectivity fMRI (RS-fMRI) is a task-free method that may be used to identify cognitive networks. We developed a voxelwise RS-fMRI metric, Functional Connectivity Hemispheric Contrast (FC-HC), to map the language network and determine language laterality through comparison of within-hemispheric language network connections (Integration) to cross-hemispheric connections (Segregation). For the first time, we demonstrated robustness and efficacy of a RS-fMRI metric to map language networks across five groups (total N = 243) that differed in MRI scanning parameters, fMRI scanning protocols, age, and development (typical vs pediatric epilepsy). The resting state FC-HC maps for the healthy pediatric and adult groups showed higher values in the left hemisphere, and had high agreement with standard task language fMRI; in contrast, the epilepsy patient group map was bilateral. FC-HC has strong but not perfect agreement with task fMRI and thus, may reflect related and complementary information about language plasticity and compensation.
- Subjects :
- Adult
medicine.medical_specialty
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
Audiology
behavioral disciplines and activities
Functional Laterality
050105 experimental psychology
Lateralization of brain function
Task (project management)
03 medical and health sciences
Epilepsy
0302 clinical medicine
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Child
RC346-429
Language
Brain Mapping
Resting state fMRI
fMRI
05 social sciences
Contrast (statistics)
Cognitive network
medicine.disease
Magnetic Resonance Imaging
Language mapping
Neurology
Metric (mathematics)
Laterality
Neurology. Diseases of the nervous system
Neurology (clinical)
Psychology
psychological phenomena and processes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22131582
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- NeuroImage: Clinical
- Accession number :
- edsair.doi.dedup.....cf928862338c76fa6c06a2bd1b68cb81