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Correlation of changes in hemodynamic response as measured by cerebral optical spectrometry with subjective pain ratings in volunteers and patients: a prospective cohort study
- Source :
- Journal of Pain Research
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Andreas Eisenried,1,2 Naola Austin,1 Benjamin Cobb,1 Alireza Akhbardeh,3 Brendan Carvalho,1 David C Yeomans,1 Alexander Z Tzabazis1,4 1Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA; 2Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany; 3ROPAmedics LLC, San Francisco, CA, USA; 4Department of Anesthesiology and Critical Care, University Hospital Schleswig-Holstein, Lübeck, Germany Purpose: Noninvasive cerebral optical spectrometry is a promising candidate technology for the objective assessment physiological changes during pain perception. This study’s primary objective was to test if there was a significant correlation between the changes in physiological parameters as measured by a cerebral optical spectrometry-based algorithm (real-time objective pain assessment [ROPA]) and subjective pain ratings obtained from volunteers and laboring women. Secondary aims were performance assessment using linear regression and receiver operating curve (ROC) analysis.Patients and methods: Prospective cohort study performed in Human Pain Laboratory and Labor and Delivery Unit. After institutional review board approval, we evaluated ROPA in volunteers undergoing the cold pressor test and in laboring women before and after epidural or combined spinal epidural placement. Linear regression was performed to measure correlations. ROCs and corresponding areas under the ROCs (AUC), as well as Youden’s indices, as a measure of diagnostic effectiveness, were calculated.Results: Correlations between numeric rating scale or visual analog scale and ROPA were significant for both volunteers and laboring women. AUCs for both volunteers and laboring women with numeric rating scale and visual analog scale subjective pain ratings as ground truth revealed at least good (AUC: 70%–79%) to excellent (AUC >90%) distinction between clinically meaningful pain severity differentiations (no/mild–moderate–severe).Conclusion: Cerebral Optical Spectrometry-based ROPA significantly correlated with subjectively reported pain in volunteers and laboring women, and could be a useful monitor for clinical circumstances where direct assessment is not available, or to complement patient-reported pain scores. Keywords: pain, assessment, objective, subjective, quantification, cerebral optical spectrometry
- Subjects :
- medicine.medical_specialty
Visual analogue scale
assessment
03 medical and health sciences
0302 clinical medicine
030202 anesthesiology
Pain assessment
Linear regression
cerebral optical spectrometry
medicine
Numeric Rating Scale
pain
030212 general & internal medicine
Journal of Pain Research
Prospective cohort study
Original Research
Receiver operating characteristic
business.industry
Cold pressor test
Institutional review board
quantification
Anesthesiology and Pain Medicine
Physical therapy
objective
business
subjective
Subjects
Details
- ISSN :
- 11787090
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Pain Research
- Accession number :
- edsair.doi.dedup.....cf8edcdf6ee9e357dfff602a79cf0cbb