Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

Authors :: Cai Ping Koh
Avinash Govind Bahirvani
Chelsia Qiuxia Wang
Tomomasa Yokomizo
Cherry Ee Lin Ng
Linsen Du
Vinay Tergaonkar
Dominic Chih-Cheng Voon
Hiroaki Kitamura
Hiroki Hosoi
Takashi Sonoki
Mok Meng Huang Michelle
Lii Jye Tan
Akiko Niibori-Nambu
Yi Zhang
Archibald S. Perkins
Zakir Hossain
Daniel G. Tenen
Yoshiaki Ito
Byrappa Venkatesh
Motomi Osato
Source :: Gene. 851:147049
Publication Year :: 2023
Publisher :: Elsevier BV, 2023.
Abstract: A cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducible CreER

Subjects :: Mice
Kinetics
Adult Stem Cells
Fetus
Core Binding Factor Alpha 2 Subunit
Genetics
Animals
Mice, Transgenic
General Medicine
Hematopoietic Stem Cells
Genetic Engineering

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