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Effects of in-vitro activity of miconazole and ketoconazole in phospholipid formulations

Authors :
A. Maccioni
Carlo Anchisi
F Alhaique
Chiara Sinico
M. L. Schivo
A De Logu
Am Fadda
Source :
The Journal of antimicrobial chemotherapy. 40(6)
Publication Year :
1998

Abstract

Antifungal agents are often used in liposomal formulations in order to improve their pharmacological activity, but how vesicle inclusion can actually affect this is still not fully understood. We report here the results obtained from evaluation of the in-vitro activity against Candida albicans ATCC E10231 of miconazole and ketoconazole in various vesicular and non-vesicular preparations, obtained from egg and soya phospholipids, using time-kill curves. In most cases inclusion of miconazole or ketoconazole in liposomes led to a delayed and decreased activity of the drugs, with detectable differences among the various phospholipid concentrations and different liposomal preparations (small unilamellar vesicle, liposomes, multilamellar aggregates and broken liposomal structures). The results obtained may be helpful in the study of new preparations of antifungal agents entrapped in liposomal structures.

Details

ISSN :
03057453
Volume :
40
Issue :
6
Database :
OpenAIRE
Journal :
The Journal of antimicrobial chemotherapy
Accession number :
edsair.doi.dedup.....cf8be1c68d8a78484d0ee354a96b3ae8