Human papillomavirus-70 infection as a possible pathogenesis of eruptive scrotal calcinosis

Genital calcinosis presents as single or multiple hard nodules in childhood and young adults. Although originally thought to represent an idiopathic condition, it is more likely that this disorder develops from dystrophic calcification of epidermoid cyst. No known publication has mentioned the relationship between scrotal calcinosis and human papillomavirus (HPV). An 18-year-old student suffered from sudden onset of multiple asymptomatic yellowish papules over the scrotum for 2 months. Skin biopsy using von Kossa stain and energy-dispersive spectrometry showing calcium deposition with a cyst formation, confirmed the diagnosis of scrotal calcinosis. The cyst wall was composed of koilocytes and multinuclear giant cells. Tissue HPV polymerase chain reaction, genotyping, and western blotting were arranged due to the above unusual observation. HPV-70 infection was detected in tissue genotyping. There were also some dilated eccrine ducts, denatured dartos muscles, and fibrous pseudocapuscule found in decalcified specimens. HPV infection over the genital area may play a role in pathogenesis of scrotal calcinosis.