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Management implications of fluorodeoxyglucose positron emission tomography/magnetic resonance in untreated intrahepatic cholangiocarcinoma
- Publication Year :
- 2020
-
Abstract
- Intrahepatic cholangiocarcinoma (ICC) is associated with a poor prognosis with surgical resection offering the best chance for long-term survival and potential cure. However, in up to 36% of patients who undergo surgery, more extensive disease is found at time of operation requiring cancellation of surgery. PET/MR is a novel hybrid technology that might improve local and whole-body staging in ICC patients, potentially influencing clinical management. This study was aimed to investigate the possible management implications of PET/MR, relative to conventional imaging, in patients affected by untreated intrahepatic cholangiocarcinoma. Retrospective review of the clinicopathologic features of 37 patients with iCCC, who underwent PET/MR between September 2015 and August 2018, was performed to investigate the management implications that PET/MR had exerted on the affected patients, relative to conventional imaging. Of the 37 patients enrolled, median age 63.5 years, 20 (54%) were female. The same day PET/CT was performed in 26 patients. All patients were iCCC-treatment-naive. Conventional imaging obtained as part of routine clinical care demonstrated early-stage resectable disease for 15 patients and advanced stage disease beyond the scope of surgical resection for 22. PET/MR modified the clinical management of 11/37 (29.7%) patients: for 5 patients (13.5%), the operation was cancelled due to identification of additional disease, while 4 “inoperable” patients (10.8%) underwent an operation. An additional 2 patients (5.4%) had a significant change in their operative plan based on PET/MR. When compared with standard imaging, PET/MR significantly influenced the treatment plan in 29.7% of patients with iCCC. 2018P001334
- Subjects :
- Male
medicine.medical_specialty
Poor prognosis
Magnetic Resonance Spectroscopy
Medizin
030218 nuclear medicine & medical imaging
Cholangiocarcinoma
Fluorodeoxyglucose positron emission tomography
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Treatment plan
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Intrahepatic Cholangiocarcinoma
Neoplasm Staging
Retrospective Studies
medicine.diagnostic_test
Extensive Disease
business.industry
Magnetic resonance imaging
General Medicine
Middle Aged
Magnetic Resonance Imaging
Bile Duct Neoplasms
Management implications
Positron-Emission Tomography
030220 oncology & carcinogenesis
Female
Radiology
Radiopharmaceuticals
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....cf7047507d3bf591495f5918c55aaacd