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Erratum: A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

Authors :
Sara Lusa
I Sana
Guido Kroemer
P. Buonpensiero
C A Leone
Maria Chiara Maiuri
Eleonora Ferrari
Angela Sepe
Stefano Guido
G. De Rosa
Antonella Tosco
Gianni Bona
Speranza Esposito
Gautier Stoll
D. De Stefano
A. Di Pasqua
R. Grassia
Luigi Maiuri
Laura Salvadori
F. De Gregorio
Anil Mehta
Valeria Raia
Tosco, Antonella
de Gregorio, F.
Esposito, S.
de Stefano, D.
Sana, I.
Ferrari, E.
Sepe, A.
Salvadori, L.
Buonpensiero, Paolo
Di Pasqua, A.
Grassia, R.
Leone, C. A.
Guido, Stefano
DE ROSA, Giuseppe
Lusa, Sara
Bona, G.
Stoll, G.
Maiuri, MARIA CHIARA
Mehta, A.
Kroemer, G.
Maiuri, L.
Raia, Valeria
Source :
Cell Death and Differentiation
Publication Year :
2016
Publisher :
Springer Science and Business Media LLC, 2016.

Abstract

We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here we provide the proof-of-concept that this combination treatment restored CFTR function and reduced lung inflammation (P

Details

ISSN :
14765403 and 13509047
Volume :
24
Database :
OpenAIRE
Journal :
Cell Death & Differentiation
Accession number :
edsair.doi.dedup.....cf5ac50121375b628994ed86c211a7c4
Full Text :
https://doi.org/10.1038/cdd.2016.43