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Erratum: A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR
- Source :
- Cell Death and Differentiation
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here we provide the proof-of-concept that this combination treatment restored CFTR function and reduced lung inflammation (P
- Subjects :
- 0301 basic medicine
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Pharmacology
Cystic fibrosis
Catechin
chemistry.chemical_compound
Mice
0302 clinical medicine
Medicine
Respiratory function
Child
Lung
Mice, Knockout
biology
Homozygote
respiratory system
Cystic fibrosis transmembrane conductance regulator
030220 oncology & carcinogenesis
Drug Therapy, Combination
Corrigendum
congenital, hereditary, and neonatal diseases and abnormalities
Programmed cell death
Adolescent
Cysteamine
03 medical and health sciences
In vivo
Autophagy
Animals
Humans
Interleukin 8
Molecular Biology
Original Paper
business.industry
Tumor Necrosis Factor-alpha
Interleukin-8
Sputum
Cell Biology
medicine.disease
respiratory tract diseases
Disease Models, Animal
030104 developmental biology
chemistry
Immunology
Mutation
biology.protein
business
Biomarkers
Subjects
Details
- ISSN :
- 14765403 and 13509047
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Cell Death & Differentiation
- Accession number :
- edsair.doi.dedup.....cf5ac50121375b628994ed86c211a7c4
- Full Text :
- https://doi.org/10.1038/cdd.2016.43