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Kinetics of the coagulation cascade including the contact activation system: sensitivity analysis and model reduction
- Source :
- Biomechanics and Modeling in Mechanobiology, Biomechanics and Modeling in Mechanobiology, Springer Verlag, 2019, 18, pp.1139-1153, Biomechanics and Modeling in Mechanobiology, Springer Verlag, 2019, 18 (4), pp.1139-1153. ⟨10.1007/s10237-019-01134-4⟩
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- International audience; Thrombus formation is one of the main issues in the development of blood-contacting medical devices. This article focuses on the modeling of one aspect of thrombosis, the coagulation cascade, which is initiated by the contact activation at the device surface and forms thrombin. Models exist representing the coagulation cascade by a series of reactions, usually solved in quiescent plasma. However, large parameter uncertainty involved in the kinetic models can affect the predictive capabilities of this approach. In addition, the large number of reactions of the kinetic models prevents their use in the simulation of complex flow configurations encountered in medical devices. In the current work, both issues are addressed to improve the applicability and fidelity of kinetic models. A sensitivity analysis is performed by two different techniques to identify the most sensitive parameters of an existing detailed kinetic model of the coagulation cascade. The results are used to select the form of a novel reduced model of the coagulation cascade which relies on eight chemical reactors only. Then, once its parameters have been calibrated thanks to the Bayesian inference, this model shows good predictive capabilities for different initial conditions.
- Subjects :
- Work (thermodynamics)
Computer science
[SDV]Life Sciences [q-bio]
Bayesian inference
0206 medical engineering
Kinetics
Flow (psychology)
02 engineering and technology
Models, Biological
Contact activation
Humans
Computer Simulation
Coagulation cascade modeling
Sensitivity (control systems)
Blood Coagulation
[PHYS]Physics [physics]
[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Mechanics of the fluids [physics.class-ph]
Model reduction
Mechanical Engineering
Thrombin
Bayes Theorem
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
Chemical reactor
020601 biomedical engineering
Modeling and Simulation
MESH: Blood coagulation/physiology
Computor simulation
Sensitivity analysis
Reduction (mathematics)
Biological system
Biotechnology
Subjects
Details
- ISSN :
- 16177940 and 16177959
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Biomechanics and Modeling in Mechanobiology
- Accession number :
- edsair.doi.dedup.....cf59157bb8a411ca9cd1b7648ffb1a08