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Correlation between the AMADEUS score and preoperative clinical patient-reported outcome measurements (PROMs) in patients undergoing matrix-induced autologous chondrocyte implantation (MACI)
- Source :
- Journal of Orthopaedic Surgery and Research, Journal of Orthopaedic Surgery and Research, Vol 14, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Recently, the AMADEUS (Area Measurement And DEpth Underlying Structures) grading system has been introduced to evaluate and grade osteochondral lesions prior to cartilage surgery. The AMADEUS score has not been connected to clinical data in order to test a potential clincial impact. Purpose To examine the correlation between the AMADEUS score and preoperative patient-reported outcome measurements (PROMs). Study design Case series Methods Patients treated with matrix-induced autologous chondrocyte implantation (MACI) were included in the study, unless exclusion criteria like BMI > 35, prior extensive meniscectomy or ongoing inflammatory arthritis were present. Preoperative magnetic resonance (MR) examinations were graded according to the standardized AMADEUS protocol. The final AMADEUS score was correlated with preoperative patient-reported outcome measurements (PROMs), including the IKDC (International Knee Documentation Committee), the Lysholm score, the Short-Form-12 (SF-12) score, and the Core Outcome Measures Index (COMI) score. Results A total of 50 patients with a mean age of 33.6 ± 11.5 years, a mean BMI of 25.1 ± 4.9, and a mean defect size of 2.3 ± 1.5 cm2 were included in the study. More severe cartilage defects, indicated by the AMADEUS grade (R = 0.35, p = 0.01) and the AMADEUS score (R = − 0.36, p = 0.01) as well as larger chondral defects (R = 0.32, p = 0.03) show a moderate correlation with the higher COMI scores. No correlative capacity was demonstrated for the AMADEUS score and the IKDC, Lysholm, and Tegner activity scores as well as for its subscales. Conclusion There is a moderate correlation of the COMI and the AMADEUS score in patients treated with matrix-induced autologous chondrocyte implantation (MACI). All other patient-reported outcome measurement scores (PROMs) show no evidence of an association to the magnetic resonance-based AMADEUS score. Clinical relevance The clinical and scientific implication of the COMI score as a PROM tool can be recommended when working with the AMADEUS score and patients undergoing MACI.
- Subjects :
- Adult
Male
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
AMADEUS score
Prom
Severity of Illness Index
Transplantation, Autologous
Correlation
03 medical and health sciences
Chondrocytes
0302 clinical medicine
lcsh:Orthopedic surgery
Preoperative Care
medicine
Humans
Matrix-induced autologous chondrocyte implantation
Orthopedics and Sports Medicine
In patient
Patient Reported Outcome Measures
Autologous chondrocyte implantation
030203 arthritis & rheumatology
030222 orthopedics
medicine.diagnostic_test
business.industry
Mean age
Magnetic resonance imaging
Middle Aged
Surgery
lcsh:RD701-811
Treatment Outcome
Patient-reported outcome measures
MACI
Orthopedic surgery
Female
Chondral lesions
Patient-reported outcome
lcsh:RC925-935
business
Cartilage Diseases
Research Article
Subjects
Details
- ISSN :
- 1749799X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Orthopaedic Surgery and Research
- Accession number :
- edsair.doi.dedup.....cf5319f6ef4fdba01a094e98689865cb