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Aberrant Distributions and Relationships Among E-cadherin, β-catenin, and Connexin 26 and 43 in Endometrioid Adenocarcinomas
- Source :
- International Journal of Gynecological Pathology. 29:358-365
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- During carcinogenesis, loss of intracellular cohesion is observed among cancer cells with altered expression of such adhesion molecules as E-cadherin and beta-catenin, and aberrant expression and cellular location of intercellular gap junction proteins-connexins. The aim of this study was to evaluate immunohistochemically the expression and relationship between E-cadherin and beta-catenin, and the connexins Cx26 and Cx43 in 86 endometrioid adenocarcinomas. The aberrant cytoplasmic translocation of the studied proteins was a predominant finding, whereas only a minority of cases showed normal, nuclear beta-catenin labeling or membranous distribution of the remaining molecules. E-cadherin was positively and significantly associated with beta-catenin (P=0.001, r=0.366), as was Cx26 with Cx43 (P0.001, r=0.719), E-cadherin with Cx26 (P0.001, r=0.413), and E-cadherin and Cx43 (P0.001, r=0.434) in all cancers. A subgroup of endometrioid adenocarcinomas (FIGO IB+II) exclusively showed a positive significant association between the expression of beta-catenin and Cx26 (P=0.038, r=0.339). In addition, there were significantly more beta-catenin-positive carcinomas among superficially spreading cancers (FIGO IA) than among deeper invading neoplasms (FIGO IB+II) (P=0.056). The altered location of the studied proteins indicates impairment of their physiological functions. In particular, normal membranous distribution of E-cadherin and connexins is lost and replaced by abnormal cytoplasmic accumulation in most cancers, and thus intercellular ties are expected to be weakened and loosened as a consequence. In contrast, the lack of relationship between beta-catenin and connexins, E-cadherin seems to be closely associated with the expression of Cx26 and Cx43 in endometrioid adenocarcinomas.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Connexin
Biology
medicine.disease_cause
Connexins
Statistics, Nonparametric
Pathology and Forensic Medicine
medicine
Humans
beta Catenin
Aged
Aged, 80 and over
Cadherin
Cell adhesion molecule
Gap junction
Obstetrics and Gynecology
Middle Aged
Cadherins
Immunohistochemistry
Endometrial Neoplasms
Connexin 26
Connexin 43
Catenin
Cancer cell
Female
Carcinogenesis
Carcinoma, Endometrioid
Intracellular
Subjects
Details
- ISSN :
- 02771691
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecological Pathology
- Accession number :
- edsair.doi.dedup.....cf4de8bcc15ca6b9655d1307e2732584