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Tumor 5-FU-related mRNA Expression and Efficacy of Oral Fluoropyrimidines in Adjuvant Chemotherapy of Colorectal Cancer
- Source :
- Anticancer research. 36(10)
- Publication Year :
- 2016
-
Abstract
- Background: It has not been elucidated whether the clinical efficacy of oral fluoropyrimidines for adjuvant chemotherapy of colorectal cancer varies with tumor biological characteristics. Patients and Methods: A multicenter randomized trial was performed comparing oral tegafur/gimeracil/oteracil (S-1) and uracil-tegafur/ leucovorin (UFT/LV) as adjuvant therapy for stage III colorectal cancer. Postoperative survival was compared based on the 5-FU-related mRNA levels in cancer tissues. Results: Among patients with tumor expressing dihydropyrimidine dehydrogenase (DPD) mRNA within the 66.7th percentile (lower 2/3) of all cases, overall survival (OS) was significantly better in the S-1 than in the UFT/LV group. In the S-1 group, patients with low DPD-expressing tumors had significantly better OS than those with highly expressing tumors. Patients with low thymidine synthase (TS)-expressing tumors had significantly better OS than those with highly expressing tumors. Conclusion: The efficacy of oral fluoropyrimidines as adjuvant chemotherapy for colorectal cancer may be influenced by the level of 5-FU-related mRNA in cancer tissues.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Antimetabolites, Antineoplastic
Adjuvant chemotherapy
Colorectal cancer
Orotate Phosphoribosyltransferase
Mrna expression
Leucovorin
Administration, Oral
Tegafur
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Dihydropyrimidine dehydrogenase
Adjuvant therapy
Humans
RNA, Messenger
Dihydrouracil Dehydrogenase (NADP)
Aged
Thymidine Phosphorylase
business.industry
Carcinoma
Cancer
General Medicine
Thymidylate Synthase
Middle Aged
medicine.disease
Drug Combinations
Oxonic Acid
Tetrahydrofolate Dehydrogenase
030104 developmental biology
Treatment Outcome
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
Female
Fluorouracil
business
Colorectal Neoplasms
medicine.drug
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 36
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.doi.dedup.....cf4d913601deef75dc8105e07c86044a