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Period of Freedom from Relapse as an Indication of Cure in Minimal Change Nephrotic Syndrome in Adults

Period of Freedom from Relapse as an Indication of Cure in Minimal Change Nephrotic Syndrome in Adults

Authors :
Yasuji Mizumura
Hiroshi Kida
Hiroyuki Iida
Yasushi Nakamoto
Jugoro Takeuchi
Kazuhiro Dohi
Source :
Nephron. 19:153-157
Publication Year :
1977
Publisher :
S. Karger AG, 1977.

Abstract

17 adult-onset nephrotic patients with minimal-change glomerular lesions experienced 39 relapses in all. The relationship between the remission period t (expressed in months) preceding each relapse and the rate of relapse (relapse rate) F (t) was proven to correspond closely to Weibull's distribution function as follows (chi 2 = 1.72, 0.5 less than p less than 0.75): In In (formula - see text) From the equation, the time when 99% of relapsing patients have relapsed is 39.3 months. This means that adult-relapsing nephrotic patients with minimal-change lesions will experience a relapse within 39.3 months of remission. They should be free from relapse and considered cured with a 99% reliability when remission has continued longer than 39.3 months, i.e. beyond the 'period of freedom from relapse'.

Details

ISSN :
22353186 and 16608151
Volume :
19
Database :
OpenAIRE
Journal :
Nephron
Accession number :
edsair.doi.dedup.....cf467f07f825970b59c66c2561cd2683
Full Text :
https://doi.org/10.1159/000180880