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Bone Mineral Density in Adolescent Girls with Hypogonadotropic and Hypergonadotropic Hypogonadism
- Source :
- Journal of Clinical Research in Pediatric Endocrinology
- Publication Year :
- 2016
- Publisher :
- Galenos Yayinevi, 2016.
-
Abstract
- Objective Deficiency of sex steroids has a negative impact on bone mineral content. In studies conducted on postmenopausal women and animal studies, elevated follicle-stimulating hormone (FSH) levels were found to be correlated with a decrease in bone mineralization and osteoporosis. The aim of the present study was to evaluate bone mineral density (BMD) in adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism and also to investigate the correlation between FSH level and BMD. Methods The study group included 33 adolescent girls with hypogonadism (14 with hypogonadotropic hypogonadism and 19 with hypergonadotropic hypogonadism). FSH, luteinizing hormone, estradiol levels, and BMD (using dual energy x-ray absorptiometry) were measured. Results There were no statistically significant differences between the chronological age and bone age of the two patient groups, namely, with hypogonadotropic and hypergonadotropic hypogonadism. There was also no significant difference between BMD z-score values obtained from measurements from the spine and the femur neck of patients in the two groups (p-values were 0.841 and 0.281, respectively). In the hypergonadotropic group, a moderately negative correlation was detected between FSH level and BMD z-score measured from the femur neck (ρ=-0.69, p=0.001), whilst no correlation was observed between FSH levels and height adjusted BMD-z scores measured from the spine (ρ=0.17, p=0.493). FSH level was not found to be an independent variable affecting BMD z-score. Conclusion BMD z-scores were detected to be similar in adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism, and FSH levels were not found to have a clinically relevant impact on BMD.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
Adolescent
Bone density
Endocrinology, Diabetes and Metabolism
Osteoporosis
030209 endocrinology & metabolism
03 medical and health sciences
Follicle-stimulating hormone
Absorptiometry, Photon
0302 clinical medicine
Endocrinology
Hypergonadotropic hypogonadism
Bone Density
Hypogonadotropic hypogonadism
030225 pediatrics
Internal medicine
medicine
Humans
follicle-stimulating hormone
Bone mineral
business.industry
Hypogonadism
Bone age
musculoskeletal system
medicine.disease
osteoporosis
Pediatrics, Perinatology and Child Health
Female
Original Article
Follicle Stimulating Hormone
business
Luteinizing hormone
Subjects
Details
- ISSN :
- 13085727
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Research in Pediatric Endocrinology
- Accession number :
- edsair.doi.dedup.....cf373bd4eb1beb4dde6ed4eac791039d