Hydrolysis of long-chain alkyl phosphates and phosphatidic acid by an enzyme purified from pig brain*†

SUMMARY Particulate preparations of rat and pig tissues have been found to catalyze the hydrolysis of lipid phosphates including many alcohol dihydrogen phosphates as well as phosphatidic acids. A soluble extract possessing these enzymatic activities has been prepared from a dried acetone extract of pig brain, and its properties are described. Evidence presented suggests that the enzyme catalyzing the hydrolysis of the alcohol dihydrogen phosphates studied here is identical with phosphatidic acid phosphatase.