Back to Search
Start Over
Strategies to Address Challenges in Neuroscience Drug Discovery and Development
- Source :
- International Journal of Neuropsychopharmacology
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- The paucity of novel drugs for neuropsychiatric indications contrasts with the remarkable recent advances in neuroscience research. We have identified 5 challenges the field needs to address and recommend potential solutions. First, we need to drive discovery efforts based on human data. Second, we need to think more carefully about animal models, embracing them as tools to test pathophysiological alterations. Third, we need to develop strategies to select more homogenous groups of patients in our clinical trials. Fourth, we need to develop and validate translational biomarkers, which can be used for pharmacodynamic assessments as well as for patient selection. Fifth, we need to adopt more reliable and objective measures to capture clinical efficacy. The tools that will allow these solutions to be implemented may already be in place but not routinely adopted or are still being developed. Overall, a change in mindset to adopt science- and data-driven paths is needed.
- Subjects :
- 0301 basic medicine
Computer science
Mindset
Field (computer science)
Translational Research, Biomedical
03 medical and health sciences
0302 clinical medicine
Animal model
target discovery
Drug Discovery
Animals
Humans
neuropsychiatry
Pharmacology (medical)
Clinical efficacy
Pharmacology
Psychotropic Drugs
clinical trials
Drug discovery
Mental Disorders
Neurosciences
biomarkers
Trends and Perspectives
Data science
Clinical trial
Psychiatry and Mental health
030104 developmental biology
Neuroscience research
030217 neurology & neurosurgery
patient selection
Subjects
Details
- ISSN :
- 14695111 and 14611457
- Database :
- OpenAIRE
- Journal :
- International Journal of Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....cf2503b1cbbe3a2340296b43eafdaa87