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Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease
- Source :
- Annals of the New York Academy of Sciences. 1173:658-663
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.
- Subjects :
- Adult
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Heterophile
Antibodies, Viral
General Biochemistry, Genetics and Molecular Biology
Immunoglobulin G
History and Philosophy of Science
Antiphospholipid syndrome
Humans
Lupus Erythematosus, Systemic
Medicine
skin and connective tissue diseases
Antigens, Viral
Autoantibodies
Immunoassay
Lupus erythematosus
Systemic lupus erythematosus
biology
business.industry
General Neuroscience
Antibody titer
medicine.disease
Epstein-Barr Virus Nuclear Antigens
Immunoglobulin M
Ribonucleoproteins
Immunology
biology.protein
Capsid Proteins
business
Anti-SSA/Ro autoantibodies
Subjects
Details
- ISSN :
- 00778923
- Volume :
- 1173
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi.dedup.....cf1f3b1788ffa10e18c08f147ac51594