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Determination of Risk Factors Related to Supraclavicular Recurrence for Limited-Stage Small Cell Lung Cancer (SCLC) Patients
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2019
- Publisher :
- International Scientific Information, Inc., 2019.
-
Abstract
- BACKGROUND This research aimed to determine high-risk factors of supraclavicular recurrence for limited-stage small cell lung cancer (LS-SCLC) patients to discover a potential subpopulation that can benefit from prophylactic supraclavicular irradiation (PSCI). MATERIAL AND METHODS Between July 2006 and July 2011, LS-SCLC patients without supraclavicular lymph node (SCLN) involvement consecutively treated with concurrent chemo-radiation but without PSCI in the Radiotherapy Department of the Cancer Institute and Hospital of Tianjin Medical University, were retrospectively analyzed. SCLN recurrence rate, overall survival (OS), and distant metastasis-free survival (DMFS) were assessed. Binary logistic regression analysis was conducted to discover the high-risk factors related to the SCLN recurrence. The receiver operating characteristic (ROC) curves were drawn to evaluate logistic regression model prediction performance. RESULTS Eighty-eight LS-SCLC patients were analyzed in this study. During 99 months (ranging from 72 months to 124 months) for survivors, 28 (31.8%) had SCLN recurrence. There were significant differences for median DMFS and OS between LS-SCLC patients with and without SCLN recurrence. The logistic regression model revealed that lymphadenopathy at mediastinal level 2 and level 3 prior to chemotherapy were significantly associated with SCLN recurrence, which was validated by ROC. CONCLUSIONS Lymphadenopathy at mediastinal level 2 and level 3 prior to chemotherapy were the high-risk factors associated with SCLN recurrence for patients with LS-SCLC. Further work is needed to determine whether patients with these factors can benefit from PSCI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Lung Neoplasms
Adolescent
medicine.medical_treatment
Limited stage small cell lung cancer
030204 cardiovascular system & hematology
Logistic regression
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Clinical Research
Humans
Medicine
Young adult
Survival analysis
Aged
Neoplasm Staging
Chemotherapy
Radiotherapy
Receiver operating characteristic
business.industry
Cancer
General Medicine
Middle Aged
Local Lymph Node Assay
medicine.disease
Clavicle
Small Cell Lung Carcinoma
Survival Analysis
Supraclavicular lymph nodes
Logistic Models
medicine.anatomical_structure
ROC Curve
030220 oncology & carcinogenesis
Female
Lymph Nodes
Radiology
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 16433750
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Medical Science Monitor
- Accession number :
- edsair.doi.dedup.....cf0c02ace7b4cff194fdfce329e3807c