Back to Search
Start Over
Metabolic side effects of atypical antipsychotics in older adults
- Source :
- International Psychogeriatrics. 30:1557-1566
- Publication Year :
- 2018
- Publisher :
- Cambridge University Press (CUP), 2018.
-
Abstract
- Background:The atypical antipsychotics (AAPs) are associated with a recognized class effect of glucose and lipid dysregulation. The use of these medications is rapidly increasing in elderly patients with, and without, dementia. However, the metabolic risks specific to elderly remain poorly studied.Methods:Design: A case-control study.Setting: Psychogeriatric service in Auckland, New Zealand.Participants: Elderly patients either receiving AAP treatment (cases) or not (controls) between 1 Jan 2008 and 1 Jan 2014.Main outcome measures: metabolic data of glucose, HbA1c, lipids, and cardiovascular events and death. The data were analyzed usingt-tests and linear regression models for each metabolic outcome.Results:There were 330 eligible cases and 301 controls from a total study population of 5,307. There was a statistically significant change in the HbA1c over time, within the cases group of −1.14 mmol/mol (p = 0.018, 95% CI −0.19 to −2.09). Also statistically significant was the reduction in total cholesterol of −0.13 mmol/L (p = 0.036, 95% CI −0.008 to −0.245). The only significant difference found between cases and controls was in the change in cholesterol ratio of 0.16 mmol/L between groups (95%CI 0.01–0.31, p = 0.036).Conclusions:AAP use was not associated with any clinically significant change in metabolic outcomes in this study population.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Class effect
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Metabolic Diseases
Total cholesterol
Internal medicine
medicine
Humans
Dementia
Aged
Cholesterol
business.industry
Significant difference
Outcome measures
medicine.disease
Lipids
030227 psychiatry
Psychiatry and Mental health
Clinical Psychology
chemistry
Population study
Female
Geriatrics and Gerontology
business
Gerontology
030217 neurology & neurosurgery
Antipsychotic Agents
Subjects
Details
- ISSN :
- 1741203X and 10416102
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- International Psychogeriatrics
- Accession number :
- edsair.doi.dedup.....cf0a22991ebbf6f917926beedc1498f8