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Regular consumption of a cocoa product improves the cardiometabolic profile in healthy and moderately hypercholesterolaemic adults
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2013
- Publisher :
- Cambridge University Press (CUP), 2013.
-
Abstract
- Cocoa products present great health potential due to their high content of polyphenols, mainly of flavanols. However, the antioxidant, anti-inflammatory and other health effects of regularly consuming cocoa products seem to depend on the intake and health status of the consumer, etc. and need to be further clarified. A randomised, controlled, cross-over, free-living study was carried out in healthy (n 24) and moderately hypercholesterolaemic (>2000mg/l, n 20) subjects to assess the influence of regularly consuming (4 weeks) two servings (15g each) of a cocoa product rich in fibre (containing 33·9% of total dietary fibre (TDF) and 13·9mg/g of soluble polyphenols) in milk v. consuming only milk (control) on (1) serum lipid and lipoprotein profile, (2) serum malondialdehyde levels, carbonyl groups, ferric reducing/antioxidant power, oxygen radical absorbance capacity and free radical-scavenging capacity, (3) IL-1β, IL-6, TNF-α, IL-10, IL-8, monocyte chemoattractant protein-1, and vascular and intracellular cell adhesion molecule levels, and (4) systolic and diastolic blood pressure and heart rate. Throughout the study, the diet and physical activity of the volunteers, as well as any possible changes in weight or other anthropometric parameters, were also evaluated. The intake of TDF increased (P<br />Project Consolider-Ingenio (CSD 2007-00063) from the Spanish Ministry of Science and Innovation.
- Subjects :
- Adult
Blood Glucose
Dietary Fiber
Male
Antioxidant
Oxygen radical absorbance capacity
Health Status
medicine.medical_treatment
Hypercholesterolemia
Anti-Inflammatory Agents
Medicine (miscellaneous)
Inflammation
Blood Pressure
Antioxidants
Protein Carbonylation
Young Adult
chemistry.chemical_compound
Heart Rate
Reference Values
Malondialdehyde
Heart rate
medicine
Humans
Hypoglycemic Agents
Food science
Cacao
Nutrition and Dietetics
Cocoa polyphenols
Cholesterol
Anticholesteremic Agents
Cholesterol, HDL
Polyphenols
HDL-cholesterol
Blood pressure
chemistry
Cardiovascular Diseases
Dietary fibre
Cytokines
Female
Plant Preparations
medicine.symptom
Adhesion molecules
Cell Adhesion Molecules
Weight gain
Phytotherapy
Lipoprotein
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....cef75c88db2c3356c1783455adcf29a7