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Effect of water content in perchloric acid on the non-aqueous potentiometric titration of nitrogen-containing compounds
- Source :
- Journal of pharmaceutical and biomedical analysis. 16(3)
- Publication Year :
- 1998
-
Abstract
- In the United States Pharmacopeia (USP), 0.1 N perchloric acid in acetic acid volumetric solution (hereafter HClO4 VS) used for non-aqueous titration has specified a water content between 0.02 and 0.05%. Preparing this titrant with such a narrow range of water content is very time consuming, precludes the use of commercially available titrants, and, consequently, prompted an investigation to try and expand the range up to 0.5%. In this study, the titrimetric results obtained using HClO4 VS containing more water were very close to those obtained using the USP specified titrants. A maximum assay difference of 0.7% in the titrations of three selected nitrogen-containing compounds, clonidine hydrochloride, dipyridamole, and adenosine were observed. The titrimetric results obtained using these titrants were also precise with RSDs of not more than 0.4%. Therefore, a wider range of water content in HClO4 VS between 0.02 and 0.5% is suggested for the USP potentiometric titration of nitrogen-containing compounds.
- Subjects :
- Clinical Biochemistry
Inorganic chemistry
Potentiometric titration
Nitro compound
Pharmaceutical Science
chemistry.chemical_element
Analytical Chemistry
chemistry.chemical_compound
Acetic acid
Drug Discovery
Perchloric acid
Nitrogen Compounds
Water content
Spectroscopy
chemistry.chemical_classification
Aqueous solution
Chromatography
Perchlorates
Water
Mercury
Nitrogen
Solutions
chemistry
Potentiometry
Titration
Indicators and Reagents
Subjects
Details
- ISSN :
- 07317085
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical and biomedical analysis
- Accession number :
- edsair.doi.dedup.....cef08e43754102e5b8c5edb36e770144