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Irregular Defects in Hepatocellular Carcinomas During the Kupffer Phase of Contrast-Enhanced Ultrasonography with Perfluorobutane Microbubbles: Pathological Features and Metastatic Recurrence After Surgical Resection
- Source :
- Ultrasound in Medicine & Biology. 43:1829-1836
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The present study aimed to elucidate the association between post-vascular–phase (Kupffer-phase) images from contrast-enhanced ultrasonography (CEUS) with perfluorobutane microbubbles and metastatic recurrences after the resection of hepatocellular carcinoma (HCC). The study examined 73 patients with solitary HCC ≤5 cm in diameter who underwent CEUS before resection. HCC was defined as irregular type (including an irregular defect on Kupffer-phase images) or non-irregular type. Intrahepatic metastatic recurrence was defined as >3 intrahepatic recurrences. Metastatic recurrence included both extrahepatic and intrahepatic recurrences. Frequencies of microscopic portal invasion and intrahepatic metastasis were significantly higher in the irregular group than in the non-irregular group. Cumulative 5-y metastatic recurrence rates in the irregular and non-irregular groups were 43% and 7% (p = 0.028), respectively. Multivariate analyses identified Kupffer-phase findings as a factor significantly related to metastatic recurrence. In conclusion, HCCs with an irregular defect during Kupffer-phase CEUS are characterized by more frequent microscopic vascular invasion and intrahepatic metastasis and are significantly associated with metastatic recurrence after resection.
- Subjects :
- Adult
Male
Surgical resection
medicine.medical_specialty
Pathology
Carcinoma, Hepatocellular
Acoustics and Ultrasonics
Biophysics
Contrast Media
030218 nuclear medicine & medical imaging
Resection
Metastasis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Pathological
Aged
Retrospective Studies
Ultrasonography
Aged, 80 and over
Fluorocarbons
Microbubbles
Radiological and Ultrasound Technology
Perfluorobutane
business.industry
Liver Neoplasms
Neoplasms, Second Primary
Middle Aged
Image Enhancement
medicine.disease
Liver
chemistry
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Female
Radiology
business
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Medicine & Biology
- Accession number :
- edsair.doi.dedup.....cedb80b7f655e5b356c0505d38191756