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Treatment of Left Anterior Descending Coronary Artery Disease With Sirolimus-Eluting Stents
- Source :
- Circulation. 110:374-379
- Publication Year :
- 2004
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2004.
-
Abstract
- Background— Revascularization strategies often hinge on the presence and degree of left anterior descending coronary artery (LAD) stenosis. A decision for bypass surgery is often based on the durability of surgical LAD revascularization compared with percutaneous approaches. By decreasing restenosis, drug-eluting stents may have reduced the “reintervention gap” between surgery and percutaneous intervention, making the percutaneous route preferable. Methods and Results— Of the 1101 patients in the SIRIUS trial, 459 with an LAD stenosis were randomized to percutaneous intervention with either sirolimus-eluting or bare-metal stents. Baseline demographic, clinical, and angiographic data were obtained. Patients had 1-year clinical and 8-month angiographic follow-up. Baseline characteristics were similar in both groups. The majority of lesions were tubular type B lesions (69.7%) with a mean diameter of 2.73 mm and a mean length of 14.0 mm. The binary in-stent restenosis rate was 2% for the sirolimus stent group and 41.6% for the bare-metal arm (relative risk, 0.05; 95% CI, 0.02 to 0.1; P P P =NS). Conclusions— Sirolimus-eluting stents significantly decrease revascularization rates in LAD lesions. At 1 year, sirolimus-eluting stent revascularization rates are comparable to historic single vessel bypass surgery revascularization rates.
- Subjects :
- Male
medicine.medical_specialty
Ticlopidine
Percutaneous
Premedication
medicine.medical_treatment
Myocardial Infarction
Anterior Descending Coronary Artery
Coronary Angiography
Revascularization
Cohort Studies
Coronary Restenosis
Double-Blind Method
Restenosis
Physiology (medical)
Internal medicine
Angioplasty
medicine
Humans
Life Tables
cardiovascular diseases
Angioplasty, Balloon, Coronary
Aged
Ultrasonography
Drug Implants
Sirolimus
Aspirin
business.industry
Coronary Stenosis
Anticoagulants
Stent
Middle Aged
medicine.disease
Survival Analysis
Clopidogrel
Surgery
Stenosis
Treatment Outcome
surgical procedures, operative
Bypass surgery
Cardiology
Female
Stents
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....ced3ddd412d05c71c797b1a04929b12e