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Modeling the Interaction Between the Intra-Aortic Balloon Pump and the Cardiovascular System: The Effect of Timing
- Source :
- Asaio Journal, 59(1), 30-36. LIPPINCOTT WILLIAMS & WILKINS, ASAIO journal, 59(1), 30-36. Lippincott Williams and Wilkins Ltd.
- Publication Year :
- 2013
-
Abstract
- Because of the large number of interaction factors involved, the effects of the intra-aortic balloon pump (IABP) have not been investigated deeply. To enhance its clinical efficiency and to better define indications for use, advanced models are required to test the interaction between the IABP and the cardiovascular system. A patient with mild blood pressure depression and a lowered cardiac output is modeled in a lumped parameter computational model, developed with physiologically representative elements for relevant components of circulation and device. IABP support is applied, and the moments of balloon inflation and deflation are varied around their conventional timing modes. For validation purposes, timing is adapted within acceptable ranges in ten patients undergoing IABP therapy for typical clinical indications. In both model and patients, the IABP induces a diastolic blood pressure augmentation as well as a systolic reduction in afterload. The support capabilities of the IABP benefit the most when the balloon is deflated simultaneously with ventricular contraction, whereas inflation before onset of diastole unconditionally interferes with ejection. The physiologic response makes the model an excellent tool for testing the interaction between the IABP and the cardiovascular system, and how alterations of specific IABP parameters (i.e., timing) affect this coupling.
- Subjects :
- Adult
Male
medicine.medical_specialty
Cardiac output
medicine.medical_treatment
Biomedical Engineering
Biophysics
Diastole
Hemodynamics
Bioengineering
Balloon
Biomaterials
Ventricular contraction
intra-aortic balloon pump (IABP)
Afterload
Internal medicine
timing
Medicine
Humans
Computer Simulation
Intra-aortic balloon pump
Aged
lumped parameter model
Aged, 80 and over
Intra-Aortic Balloon Pumping
business.industry
Models, Cardiovascular
General Medicine
Middle Aged
Myocardial Contraction
Blood pressure
Cardiology
cardiovascular system
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 10582916
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Asaio Journal
- Accession number :
- edsair.doi.dedup.....ced27cf6dd958f0bbc40dad40841bd8c