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Effects of a diet based on foods from symbiotic agriculture on the gut microbiota of subjects at risk for metabolic syndrome
- Source :
- Nutrients, Vol 13, Iss 2081, p 2081 (2021), Nutrients, Volume 13, Issue 6
- Publication Year :
- 2021
-
Abstract
- Diet is a major driver of gut microbiota variation and plays a role in metabolic disorders, including metabolic syndrome (MS). Mycorrhized foods from symbiotic agriculture (SA) exhibit improved nutritional properties, but potential benefits have never been investigated in humans. We conducted a pilot interventional study on 60 adults with ≥ 1 risk factors for MS, of whom 33 consumed SA-derived fresh foods and 27 received probiotics over 30 days, with a 15-day follow-up. Stool, urine and blood were collected over time to explore changes in gut microbiota, metabolome, and biochemical, inflammatory and immunologic parameters<br />previous dietary habits were investigated through a validated food-frequency questionnaire. The baseline microbiota showed alterations typical of metabolic disorders, mainly an increase in Coriobacteriaceae and a decrease in health-associated taxa, which were partly reversed after the SA-based diet. Improvements were observed in metabolome, MS presence (two out of six subjects no longer had MS) or components. Changes were more pronounced with less healthy baseline diets. Probiotics had a marginal, not entirely favorable, effect, although one out of three subjects no longer suffered from MS. These findings suggest that improved dietary patterns can modulate the host microbiota and metabolome, counteracting the risk of developing MS.
- Subjects :
- 0301 basic medicine
Male
Physiology
Pilot Projects
Urine
Gut flora
Coriobacteriaceae
Probiotic
Feces
0302 clinical medicine
TX341-641
Metabolic Syndrome
Nutrition and Dietetics
biology
Metabolic dysfunction
Symbiotic agriculture
digestive, oral, and skin physiology
pilot study
Agriculture
Middle Aged
Italy
030220 oncology & carcinogenesis
Metabolome
metabolome
Female
dietary pattern
Diet, Healthy
Human
Adult
Adolescent
dietary patterns
Dietary pattern
Gut microbiota
Article
metabolic syndrome
03 medical and health sciences
Young Adult
dietary intervention
medicine
adult volunteers
Humans
Pilot Project
Adult volunteers
Dietary intervention
Dietary patterns
Metabolic syndrome
Pilot study
Aged
metabolic dysfunction
gut microbiota
Nutrition. Foods and food supply
Probiotics
adult volunteer
biology.organism_classification
medicine.disease
Diet
Gastrointestinal Microbiome
030104 developmental biology
Fece
symbiotic agriculture
Adult volunteer
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nutrients, Vol 13, Iss 2081, p 2081 (2021), Nutrients, Volume 13, Issue 6
- Accession number :
- edsair.doi.dedup.....ced19cd11afc673f9b83dcadf7938c3e