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Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer
- Source :
- Future Oncology. 12:493-502
- Publication Year :
- 2016
- Publisher :
- Future Medicine Ltd, 2016.
-
Abstract
- Aim: To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer. Patients & methods: The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes. Results: We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3–4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival. Conclusion: The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
geriatric assessment
Antineoplastic Agents
Docetaxel
Castration resistant
Castration-Resistant
elderly
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Clinical history
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
80 and over
castration-resistant prostate cancer
Humans
Medicine
030212 general & internal medicine
Aged
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
business.industry
Proportional hazards model
Prostatic Neoplasms
Retrospective cohort study
General Medicine
medicine.disease
Prostatic Neoplasms, Castration-Resistant
Treatment Outcome
docetaxel
Retreatment
Taxoids
030220 oncology & carcinogenesis
Toxicity
First line chemotherapy
business
medicine.drug
Subjects
Details
- ISSN :
- 17448301 and 14796694
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Future Oncology
- Accession number :
- edsair.doi.dedup.....cec974fcf83835ad5eb6c8f8406e9519
- Full Text :
- https://doi.org/10.2217/fon.15.302