Back to Search
Start Over
The Host Immune Response to Tissue-Engineered Organs: Current Problems and Future Directions
- Source :
- Tissue engineering. Part B, Reviews. 22(3)
- Publication Year :
- 2015
-
Abstract
- As the global health burden of chronic disease increases, end-stage organ failure has become a costly and intractable problem. De novo organ creation is one of the long-term goals of the medical community. One of the promising avenues is that of tissue engineering: the use of biomaterials to create cells, structures, or even whole organs. Tissue engineering has emerged from its nascent stage, with several proof-of-principle trials performed across various tissue types. As tissue engineering moves from the realm of case trials to broader clinical study, three major questions have emerged: (1) Can the production of biological scaffolds be scaled up accordingly to meet current and future demands without generating an unfavorable immune response? (2) Are biological scaffolds plus or minus the inclusion of cells replaced by scar tissue or native functional tissue? (3) Can tissue-engineered organs be grown in children and adolescents given the different immune profiles of children? In this review, we highlight current research in the immunological response to tissue-engineered biomaterials, cells, and whole organs and address the answers to these questions.
- Subjects :
- 0301 basic medicine
Tissue engineered
Tissue Engineering
Tissue Scaffolds
business.industry
Scar tissue
Biomedical Engineering
Bioengineering
Biocompatible Materials
Biochemistry
Regenerative medicine
Biomaterials
Clinical study
03 medical and health sciences
030104 developmental biology
Chronic disease
Immune system
Tissue engineering
Immunology
Medicine
Humans
business
Neuroscience
Forecasting
Subjects
Details
- ISSN :
- 19373376
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Tissue engineering. Part B, Reviews
- Accession number :
- edsair.doi.dedup.....cec945777036ad878a554dd291c4dbd8