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Trisomy 8 in acute myeloid leukemia
- Source :
- Expert review of hematology. 12(11)
- Publication Year :
- 2019
-
Abstract
- Introduction: Trisomy 8 is one of the most common cytogenetic alterations in acute myeloid leukemia (AML), with a frequency between 10% and 15%.Areas covered: The authors summarize the latest research regarding biological, translational and clinical aspects of trisomy 8 in AML.Expert opinion: Trisomy 8 can be found together with other karyotypes, although it also occurs as a sole aberration. The last decade's research has brought attention to molecular genetic alterations as strong contributors of leukemogenesis. AML with trisomy 8 seems to be associated with mutations in DNA methylation genes, spliceosome complex genes, and myeloid transcription factor genes, and these alterations probably have stronger implication for leukemic pathogenesis, treatment and hence prognosis, than the existence of trisomy 8 itself. Especially mutations in the RUNX1 and ASXL1 genes occur in high frequencies, and search for such mutations should be mandatory part of the diagnostic workup. AML with trisomy 8 is classified as intermediate-risk AML after recent European Leukemia Net (ELN) classification, and hence allogenic hematopoietic stem cell transplantation (Allo-HSCT) should be consider as consolidation therapy for this patient group.Trisomy 8 is frequently occurring in AML, although future molecular genetic workup should be performed, to optimize the diagnosis and treatment of these patients.
- Subjects :
- medicine.medical_specialty
Myeloid
medicine.medical_treatment
Trisomy
Hematopoietic stem cell transplantation
Trisomy 8
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
hemic and lymphatic diseases
Molecular genetics
medicine
Humans
business.industry
Myeloid leukemia
Hematology
medicine.disease
Neoplasm Proteins
Repressor Proteins
Leukemia
Leukemia, Myeloid, Acute
medicine.anatomical_structure
RUNX1
chemistry
030220 oncology & carcinogenesis
DNA methylation
Core Binding Factor Alpha 2 Subunit
Cancer research
business
030215 immunology
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 17474094
- Volume :
- 12
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Expert review of hematology
- Accession number :
- edsair.doi.dedup.....cec4cf78e536e936ba5cf26f55bd5360