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Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress

Authors :
Julian Laubenthal
Guido R.M.M. Haenen
Eleni Fthenou
Diana Anderson
Joost O. Linschooten
Ville E. Sipinen
Jacob J. Briedé
Adolf Baumgartner
Gunnar Brunborg
Eduardo Cemeli
Roger W. L. Godschalk
Frederik J. van Schooten
RS: NUTRIM - R4 - Gene-environment interaction
Farmacologie en Toxicologie
Toxicogenomics
RS: CARIM School for Cardiovascular Diseases
RS: GROW - School for Oncology and Reproduction
Source :
Reproductive Toxicology, 32(1), 106-111. Elsevier Inc.
Publication Year :
2011
Publisher :
Elsevier Inc., 2011.

Abstract

Although DNA damage in human spermatozoa is associated with adverse health effects, its origin is not fully understood. Therefore, we assessed biomarkers in ejaculates that retrospectively reflect processes that occurred in the epididymis or testis. Smoking increased the amount of DNA strand breaks (P

Details

Language :
English
ISSN :
08906238
Volume :
32
Issue :
1
Database :
OpenAIRE
Journal :
Reproductive Toxicology
Accession number :
edsair.doi.dedup.....ceb50466d86935a7d876e0882c1534a7