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Alterations of tumour suppressor gene PPP2R1B in hepatocellular carcinoma
- Source :
- Cancer Letters. 253:138-143
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- To evaluate whether the tumour suppressor gene, PPP2R1B, is involved in pathogenesis of hepatocellular carcinoma (HCC), reverse transcription-polymerase chain reaction (RT-PCR) and cDNA sequencing were performed. Eleven of 38 (29%) tumours and 1 of 34 (3%) corresponding non-tumour tissues showed coexpression of wild-type and aberrant mRNA. Various deletions were found in aberrant transcripts. Southern blot analysis did not show gene deletion in tumours, suggesting abnormal RNA splicing may be involved. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC.
- Subjects :
- Adult
Male
Cancer Research
Carcinoma, Hepatocellular
Biology
Pathogenesis
medicine
Humans
Genes, Tumor Suppressor
Protein Phosphatase 2
Tumour suppressor gene
Aged
Southern blot
Messenger RNA
Reverse Transcriptase Polymerase Chain Reaction
Liver Neoplasms
Sequence Analysis, DNA
Protein phosphatase 2
Middle Aged
medicine.disease
Molecular biology
Neoplasm Proteins
Oncology
Hepatocellular carcinoma
RNA splicing
Cancer research
Female
Cdna sequencing
Gene Deletion
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 253
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....ceb3a13cdda406ebc25d87dfe44e07ba