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EVOLUTION OF MYELOID CELLS
- Publication Year :
- 2016
-
Abstract
- In 1882, Elie Metchnikoff identified myeloid-like cells from starfish larvae responding to the invasion by a foreign body (rose thorn). This marked the origins for the study of innate immunity, and an appreciation that cellular immunity was well established even in these “primitive” organisms. This chapter focuses on these myeloid cells as well as the newest members of this family, the dendritic cells, and explores their evolutionary origins. Our goal is to provide evolutionary context for the development of the multilayered immune system of mammals, where myeloid cells now serve as central effectors of innate immunity and regulators of adaptive immunity. Overall, we find that core contributions of myeloid cells to the regulation of inflammation are based on mechanisms that have been honed over hundreds of millions of years of evolution. Using phagocytosis as a platform, we show how fairly simple beginnings have offered a robust foundation onto which additional control features have been integrated, resulting in central regulatory nodes that now manage multifactorial aspects of homeostasis and immunity.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Cellular immunity
Physiology
Context (language use)
Inflammation
Biology
Article
03 medical and health sciences
0302 clinical medicine
Immune system
Immunity
Genetics
medicine
Animals
Myeloid Cells
Mammals
Immunity, Cellular
Innate immune system
General Immunology and Microbiology
Ecology
Effector
Cell Biology
Acquired immune system
Biological Evolution
Immunity, Innate
030104 developmental biology
Infectious Diseases
Immunology
medicine.symptom
Neuroscience
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ce9685e86cfa805c811434298c18dedc