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Alpha-1-Antichymotrypsin in Renal Biopsies
- Source :
- Nephron. 56:387-390
- Publication Year :
- 1990
- Publisher :
- S. Karger AG, 1990.
-
Abstract
- Alpha 1-Antichymotrypsin (alpha 1-AK) and alpha-1-antitrypsin (alpha 1-AT) represent a defense mechanism to protect the tissues from proteolytic enzyme activity. We studied the implication of alpha 1-AK and alpha 1-AT in glomeruli of patients with different nephropathies based on the analysis of 52 paraffin-embedded renal biopsies with alpha 1-AK and alpha 1-AT antisera. The results demonstrate an intense alpha 1-AK glomerular staining in renal biopsies from patients with minimal-change disease, while a minor staining of this protein was found in the other nephropathies. No significant evidence of alpha 1-AT deposits was observed in our cases. Our findings suggest that when alpha 1-AK is lacking in glomeruli the defense mechanisms against proteolytic enzymes may not be efficient enough to protect the glomerular structures and limit the damage. Since alpha 1-AK is a reactant of the acute phase of inflammation, it may be considered as a marker of activity for monocyte-macrophages in glomerular damage.
- Subjects :
- Pathology
medicine.medical_specialty
alpha 1-Antichymotrypsin
Renal glomerulus
Biopsy
Kidney Glomerulus
Alpha (ethology)
Monocytes
Alpha 1-antichymotrypsin
Nephropathy
medicine
Humans
Kidney
biology
medicine.diagnostic_test
business.industry
Macrophages
Proteolytic enzymes
medicine.disease
medicine.anatomical_structure
alpha 1-Antitrypsin
biology.protein
Immunohistochemistry
Kidney Diseases
Renal biopsy
business
Biomarkers
Subjects
Details
- ISSN :
- 22353186 and 16608151
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Nephron
- Accession number :
- edsair.doi.dedup.....ce8e4fd1448584322de51b2c59343ef5