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Multiomic immune clockworks of pregnancy
- Source :
- Seminars in Immunopathology
- Publication Year :
- 2020
- Publisher :
- Springer Berlin Heidelberg, 2020.
-
Abstract
- Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy “immune clock” is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth
- Subjects :
- Proteomics
Preterm labor
Placenta
Immunology
Review
Bioinformatics
Immune system
Fetus
Obstetric Labor, Premature
Pregnancy
Cytomics
Immunology and Allergy
Medicine
Metabolomics
Humans
Microbiome
Transcriptomics
Child
parturition
business.industry
Infant, Newborn
Preterm birth
medicine.disease
Multiple factors
Premature Birth
Mass cytometry
Female
Biological plausibility
business
Prematurity
multiomics
Subjects
Details
- Language :
- English
- ISSN :
- 18632300 and 18632297
- Volume :
- 42
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Seminars in Immunopathology
- Accession number :
- edsair.doi.dedup.....ce8b98ca7258cbe98390446ec723d0d2