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Supratentorial intracerebral hemorrhage volume and other CT variables predict the neurological pupil index
- Source :
- Clinical neurology and neurosurgery. 200
- Publication Year :
- 2020
-
Abstract
- Objectives There is growing interest in the ability of automated infrared pupillometry to assess severity of neurological illness. We studied the correlation between computed tomography (CT) indicators of intracerebral hemorrhage (ICH) severity with objective measures of the pupillary light reflex (PLR), and hypothesized that hemorrhage volume would predict the Neurological Pupil index™ (NPi™), an indicator of pupillary reactivity. Methods This study examined data from patients with supratentorial ICH who underwent serial pupillometer evaluations. CT images were examined to determine the location and laterality of the hemorrhage, along with hematoma volume (using the simplified ABC/2 method), midline shift, hydrocephalus score, and modified Graeb score (indicating interventricular hemorrhage). Demographics were examined with standard measures of central tendency, hypotheses with logistic regression, categorical data with Fisher’s Exact X2, and multivariate modeling with constructed MAX-R models. Results Data were gathered from 44 subjects. ICH volume exhibited the strongest correlation with NPi (ipsilateral [r2 = 0.48, p Conclusion ICH volume and shift of midline structures correlate with NPi, and abnormalities in NPi can be predicted by hematoma volume and other CT indicators of ICH severity. Future studies should explore the role of NPi in detecting early hematoma expansion and worsening midline shift.
- Subjects :
- Male
medicine.medical_specialty
Logistic regression
Reflex, Pupillary
Pupil
03 medical and health sciences
0302 clinical medicine
Hematoma
Midline shift
Predictive Value of Tests
medicine
Humans
cardiovascular diseases
Pupillary light reflex
Prospective Studies
Aged
Cerebral Hemorrhage
Retrospective Studies
Intracerebral hemorrhage
Aged, 80 and over
Neurologic Examination
business.industry
General Medicine
Middle Aged
medicine.disease
Hydrocephalus
030220 oncology & carcinogenesis
Surgery
Female
Neurology (clinical)
Radiology
business
Tomography, X-Ray Computed
030217 neurology & neurosurgery
Pupillometry
Subjects
Details
- ISSN :
- 18726968
- Volume :
- 200
- Database :
- OpenAIRE
- Journal :
- Clinical neurology and neurosurgery
- Accession number :
- edsair.doi.dedup.....ce8667279f65efbb40c5e50bfc984adf