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MR imaging features of retinoblastoma : Association with gene expression profiles
- Source :
- Radiology, 288(2), 506-515. Radiological Society of North America Inc., Jansen, R W, de Jong, M C, Kooi, I E, Sirin, S, Göricke, S, Brisse, H J, Maeder, P, Galluzzi, P, van der Valk, P, Cloos, J, Eekhout, I, Castelijns, J A, Moll, A C, Dorsman, J C & de Graaf, P 2018, ' MR Imaging Features of Retinoblastoma : Association with Gene Expression Profiles ', Radiology, vol. 288, no. 2, pp. 506-515 . https://doi.org/10.1148/radiol.2018172000
- Publication Year :
- 2018
-
Abstract
- Purpose To identify associations between magnetic resonance (MR) imaging features and gene expression in retinoblastoma. Materials and Methods A retinoblastoma MR imaging atlas was validated by using anonymized MR images from referral centers in Essen, Germany, and Paris, France. Images were from 39 patients with retinoblastoma (16 male and 18 female patients [the sex in five patients was unknown]; age range, 5-90 months; inclusion criterion: pretreatment MR imaging). This atlas was used to compare MR imaging features with genome-wide messenger RNA (mRNA) expression data from 60 consecutive patients obtained from 1995 to 2012 (35 male patients [58%]; age range, 2-69 months; inclusion criteria: pretreatment MR imaging, genome-wide mRNA expression data available). Imaging pathway associations were analyzed by means of gene enrichment. In addition, imaging features were compared with a predefined gene expression signature of photoreceptorness. Statistical analysis was performed with generalized linear modeling of radiology traits on normalized log2-transformed expression values. P values were corrected for multiple hypothesis testing. Results Radiogenomic analysis revealed 1336 differentially expressed genes for qualitative imaging features (threshold P = .05 after multiple hypothesis correction). Loss of photoreceptorness gene expression correlated with advanced stage imaging features, including multiple lesions (P = .03) and greater eye size (P < .001). The number of lesions on MR images was associated with expression of MYCN (P = .04). A newly defined radiophenotype of diffuse-growing, plaque-shaped, multifocal tumors displayed overexpression of SERTAD3 (P = .003, P = .049, and P = .06, respectively), a protein that stimulates cell growth by activating the E2F network. Conclusion Radiogenomic biomarkers can potentially help predict molecular features, such as photoreceptorness loss, that indicate tumor progression. Results imply a possible role for radiogenomics in future staging and treatment decision making in retinoblastoma.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Retinal Neoplasms
Radiogenomics
Medizin
Retina
03 medical and health sciences
0302 clinical medicine
Text mining
Gene expression
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Genes, Retinoblastoma
business.industry
Retinoblastoma
fungi
food and beverages
Infant
Reproducibility of Results
medicine.disease
Mr imaging
Magnetic Resonance Imaging
eye diseases
030220 oncology & carcinogenesis
Child, Preschool
030221 ophthalmology & optometry
Female
Mr images
business
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 00338419
- Database :
- OpenAIRE
- Journal :
- Radiology, 288(2), 506-515. Radiological Society of North America Inc., Jansen, R W, de Jong, M C, Kooi, I E, Sirin, S, Göricke, S, Brisse, H J, Maeder, P, Galluzzi, P, van der Valk, P, Cloos, J, Eekhout, I, Castelijns, J A, Moll, A C, Dorsman, J C & de Graaf, P 2018, ' MR Imaging Features of Retinoblastoma : Association with Gene Expression Profiles ', Radiology, vol. 288, no. 2, pp. 506-515 . https://doi.org/10.1148/radiol.2018172000
- Accession number :
- edsair.doi.dedup.....ce82e1efbcb2098f4515870c9be9c77a