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Maternal immune activation in mid-late gestation alters amphetamine sensitivity and object recognition, but not other schizophrenia-related behaviours in adult rats
- Source :
- Behavioural Brain Research. 356:358-364
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Maternal immune activation induced by Poly(I:C) administration is one of the most commonly used animal models of schizophrenia at present. Previous work from our team has demonstrated that some, but not all of the features often reported for maternal immune activation exposure in rodents can be observed in rats exposed to maternal immune activation at mid or late gestation. To determine whether previous findings in our laboratory were due to these time points simply being less sensitive neurodevelopmental periods for rats with regard to maternal immune activation effects, we aimed to investigate whether maternal immune activation at an often-reported sensitive period (mid-late gestation, day 14) resulted in more behavioural features reflective of face validity for schizophrenia. We examined the behavioural outcomes of mid-late maternal immune activation on a battery of behavioural tests aimed at assessing validity for positive, negative and cognitive symptoms of schizophrenia. We found that rats exposed to maternal immune activation, compared to controls, exhibited enhanced sensitivity to the locomotor-stimulating effects of amphetamine and reduced exploration of novel objects. These findings present a unique profile of effects, different to what has already been established for the same time point in rats, and different to what we had found at earlier and later time points. This work, among others in the literature, highlights the varying nature of models of maternal immune activation and we submit that it is essential for laboratories to characterise their models of maternal immune activation on behaviour rather than assuming that the effects from one laboratory apply in their own.
- Subjects :
- Male
Late gestation
Physiology
Motor Activity
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Pregnancy
medicine
Animals
Enhanced sensitivity
Rats, Wistar
Amphetamine
Prepulse inhibition
030304 developmental biology
0303 health sciences
Cognitive Symptoms
Behavior, Animal
business.industry
medicine.disease
Disease Models, Animal
Maternal Exposure
Schizophrenia
Prenatal Exposure Delayed Effects
Gestation
Female
business
030217 neurology & neurosurgery
medicine.drug
Immune activation
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 356
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....ce5826c5dc6e8311d5c0197c3b2a9cc2
- Full Text :
- https://doi.org/10.1016/j.bbr.2018.08.016