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Modeling transcranial electrical stimulation in the aging brain
- Source :
- Brain Stimulation, Vol 13, Iss 3, Pp 664-674 (2020), Brain Stimul
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background Varying treatment outcomes in transcranial electrical stimulation (tES) recipients may depend on the amount of current reaching the brain. Brain atrophy associated with normal aging may affect tES current delivery to the brain. Computational models have been employed to compute predicted tES current inside the brain. This study is the largest study that uses computational models to investigate tES field distribution in healthy older adults. Methods Individualized head models from 587 healthy older adults (mean = 73.9years, 51–95 years) were constructed to create field maps. Two electrode montages (F3-F4, M1-SO) with 2 mA input current were modeled using ROAST with modified codes. A customized template of healthy older adults, the UFAB-587, was created from the same dataset and used to warp individual brains into the same space. Warped models were analyzed to determine the relationship between computed field measures, brain atrophy and age. Main results Computed field measures were inversely correlated with brain atrophy (R2 = 0.0829, p = 1.14e-12). Field pattern showed negative correlation with age in brain sub-regions including part of DLPFC and precentral gyrus. Mediation analysis revealed that the negative correlation between age and current density is partially mediated by brain-to-CSF ratio. Conclusions Computed field measures showed decreasing amount of tES current reaching the brain with increasing atrophy. Therefore, adjusting current dose by modifying tES stimulation parameters in older adults based on degree of atrophy may be necessary to achieve desired stimulation benefits. Results from this study may inform future tES application in healthy older adults.
- Subjects :
- Male
Aging
Brain atrophy
medicine.medical_specialty
Finite Element Analysis
Treatment outcome
Biophysics
Stimulation
Normal aging
Audiology
Transcranial Direct Current Stimulation
Article
tDCS
050105 experimental psychology
Field pattern
lcsh:RC321-571
03 medical and health sciences
Imaging, Three-Dimensional
0302 clinical medicine
Atrophy
medicine
Humans
Aging brain
Computer Simulation
0501 psychology and cognitive sciences
tES
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Aged
Aged, 80 and over
business.industry
General Neuroscience
05 social sciences
Brain
food and beverages
Precentral gyrus
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Neurology (clinical)
Negative correlation
business
030217 neurology & neurosurgery
Finite element model
Subjects
Details
- ISSN :
- 1935861X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Brain Stimulation
- Accession number :
- edsair.doi.dedup.....ce55a4226f62b867565aedb99c9ff94d